In rare instances, doses of up to 12 grams of cefazolin per day have been used. Cefazolin may be reconstituted with dextrose or a number of other diluents as recommended in the innovators package insert in order to achieve an osmolality appropriate for intravenous infusion. Cefazolin for injection, usp is supplied in vials containing cefazolin sodium equivalent to 500 mg or 1 gram cefazolin. Blood levels of cefazolin in dialysis patients remain fairly high and should be monitored. Cefazolin medical definition merriamwebster medical. Cefazolin is also used to help prevent infection in people having certain types of surgery. This emedtv page presents treatment guidelines for this antibiotic, including how your dose is determined, how the injections are given, and more. Cefazolin, craniotomy, endstage renal disease, malnutrition, vitamin k.
Cefalotin as antimicrobial prophylaxis in patients with known. Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. Mar 15, 2020 cefazolin is a cephalosporin sef a low spor in antibiotic that is is used to treat bacterial infections, including severe or lifethreatening forms. Naloxone may not be effective in reversing respiratory depression produced by buprenorphine. In synovial fluid, the cefazolin concentration becomes comparable to that reached in serum at about 4 hours after drug administration. Cefazolin for injection, usp is supplied in 10 or 20 grams pharmacy bulk packages. Cefazolin, diclofenac sodium, goats, pharmacokinetics.
Cefazolin injection also may be used before, during, and sometimes for a brief period after surgery in order to prevent the. Safety study of cefazolin administered for surgical prophylaxis in. See dosage in patients with reduced renal function. Cefazolin injection fda prescribing information, side. It also outlines some of the reasons a doctor may prescribe the drug for unapproved purposes. The mean peak concentrations in the serum in 10 normal subjects 1 h after intramuscular injections of 1,000, 500, and 250 mg of cefazolin were 38. Cefazolin for injection, usp material safety data sheet date printed. Cefazolin is present in very low levels in the milk of nursing mothers.
Pharmacokinetics and safety of cefazolin 2g in duplex full. Jun 01, 2012 cefazolin is an antibiotic commonly used in clinical practice because of its long halflife, narrow spectrum and its ability for dose adjustment in renal failure patients. Cefazolin sodium cefazolin sodium dose, indications. To reduce the development of drugresistant bacteria and maintain the. Cefazolin was the most common individual drug responsible for intraoperative anaphylaxis in western australia in 20145, reflecting its status as firstline choice. Comparing cefepime versus cefazolin plus ceftazidime for capd.
Put residues in labeled plastic bags or other containers for disposal. Also available as pharmacy bulk package, as follows. The drug concentrates in the urine, at levels much higher than peak serum levels. Cefazolin may also be used for purposes not listed in this medication guide. Looking for online definition of cefazolin or what cefazolin stands for. This prescription drug is used for treating these types of bacterial infections and also for preventing certain infections that may occur due to surgery.
Add a pdf to your office file office support microsoft office support. This emedtv article examines specific uses for cefazolin. Word will convert the pdf to editable text and you can then copy and paste that text into your office document. Penicillin vk penicillin is good at treating strep throat and is cheap, however, it can only be used for certain infections as many bacteria have developed resistance to it. Cefazolin is a cephalosporin sef a low spor in antibiotic that is is used to treat bacterial infections, including severe or lifethreatening forms. This medication is known as a cephalosporin antibiotic. Cefazolin prescription and dosage sizes information for physicians and healthcare professionals. Cefazolin sodium definition of cefazolin sodium by medical. As with other cephalosporins, cefazolin for injection, usp tends to darken depending on storage conditions. Doxapram hydrochloride has also been used as a respiratory stimulant. Cefazolin injection is used to treat certain infections caused by bacteria including skin, bone, joint, genital, blood, heart valve, respiratory tract including pneumonia, biliary tract, and urinary tract infections. Cefazolin sodium is a cephalosporin antibiotic for parenteral administration.
Pharmacology, adverse reactions, warnings and side effects. Find out what health conditions may be a health risk when taken with cefazolin injection. Cefazolin is an antibiotic commonly used in clinical practice because of its long halflife, narrow spectrum and its ability for dose adjustment in renal failure patients. The color of rocephin solutions ranges from light yellow to amber, depending on the length of storage, concentration and diluent used. It exerts its bacterial effect by inhibiting bacterial cell wall synthesis. Patients with low urinary output due to impaired renal function should be administered reduced daily dosages of cefazolin. Cefazolin for injection usp and dextrose injection usp. Bulk package contains cefazolin sodium, usp equivalent to 10 or 20 grams of. Cefazolin generic ancef is a intravenous or intramuscular injection drug only. For a 65 lb kid the dose range is 25100 mgkgday divided into 34 doses a day.
Dec 12, 2018 ndc 0143992390 cefazolin for injection, usp 500 mgvial for iv or im use rx only each vial contains sterile cefazolin sodium equivalent to 500 mg cefazolin. Dailymed cefazolin injection, powder, for solution. The medicine is sometimes also used to prevent infections before, during, or after. Jul 12, 2018 cefazolin passes into breast milk in very low concentrations. Ndc 0143992390 cefazolin for injection, usp 500 mgvial for iv or im use rx only each vial contains sterile cefazolin sodium equivalent to 500 mg cefazolin. It has been suggested to continue cefazolin and add. Brauns approved package insert for cefazolin 1g, the maximum dose of 1. Your doctor will prescribe a cefazolin dosage that is appropriate for your age, weight, and other factors. It is also used to prevent infection before, during, and after surgery. Please tell us where you read or heard it including the quote, if possible. Webmd provides common contraindications for cefazolin injection. Cefazolin distributes into breast milk in low concentrations.
It offers the advantages of a moderately long halflife, activity against most staphylococci and streptococci in addition to some gramnegative aerobic organisms, and low cost. Pneumonia, bladder infections, or various other bacterial infections may be treated with an antibiotic called cefazolin. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for ancef cefazolin skip to. Westward pharmaceuticals 401 industrial way west, eatontown, nj 07724 phone 732 542 1191 fax 732 720 6220 technical phone. Cefazolin has a similar spectrum of activity to cephalothin, is available worldwide, and is now the only parenteral firstgeneration cephalosporin available in the united states. Cefazolin is packaged in a dry form of 1 gram, and the package directions state to add 2. Our cefazolin and dextrose for injection side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
The usual regimen in thailand is cefazolin plus ceftazidime. Cefazolin has had extensive clinical use and has proven effectiveness. Cephalosporin antibiotic relevant identified uses of the substance or mixture and uses advised against intended use. Each pharmacy bulk package contains cefazolin sodium, usp equivalent to 10 or 20 grams of cefazolin. It is also used to prevent group b streptococcal disease around the time of delivery and before surgery. Pharmacokinetics and safety of cefazolin 2g in duplex. Parenteral drug products should be shaken well when reconstituted, and inspected visually for particulate matter prior to administration. Cefazolin belongs to a group of drugs called cephalosporin antibiotics. Pr cefazolin for injection, usp cefazolin sodium powder. Store in accordance with information listed on the product insert. The ph of a 1% aqueous solution is approximately 6.
To reduce the development of drugresistant bacteria and maintain the effectiveness of. Highlights of prescribing information age group dosage. Studies of cord blood show prompt transfer of cefazolin across the placenta. Cefazolin does not reach therapeutic levels within the csf. Cefazolin is an antibiotic used to treat bacterial infections, marketed under the brand names ancef and kefzol. Cefazolin is an antibiotic commonly used in clinical practice because of its. Rouzi aa1, khalifa f, baaqeel h, alhamdan hs, bondagji n. Highlights of prescribing information these highlights do not include all the information needed to use cubicin safely and effectively. Side effects of cefazolin injection cefazolin and dextrose. Cefazolin, also known as cefazoline and cephazolin, is an antibiotic used for the treatment of a number of bacterial infections. Cefazolin side effects, uses, dosage, overdose, pregnancy. To determine the effectiveness and safety of the routine use of antibiotic prophylaxis in women undergoing cesarean section. Cefazolin and dextrose for injection is an antibiotic used to treat many different kinds of bacterial infections. Specifically it is used to treat cellulitis, urinary tract infections, pneumonia, endocarditis, joint infection, and biliary tract infections.
Dec 01, 2019 cefazolin for injection, usp is supplied in vials containing cefazolin sodium equivalent to 500 mg or 1 gram cefazolin. Before reconstitution, store at 20 to 25c 68 to 77f. Pdf pharmacokinetics of cefazolin in healthy and febrile goats and. It may also be used before and during certain surgeries to help prevent infection. Pronunciation of cefazolin sodium with 1 audio pronunciation and more for cefazolin sodium.
Potential adverse reactions from prescribed doses and overdoses are described in the package insert. Cefazolin is a prescription medication used to treat bacterial infections, including lung, skin, bone, joint, stomach, blood, heart valve, and urinary tract infections. Cefazolin, however, was two to eightfold more active than the other two drugs against escherichia coli and klebsiella. Cefazolin is licensed for adults and children who have infections caused by certain types of bacteria. Adult antimicrobial surgical prophylaxis guidelines approved xx.
Cefazolin is the most commonly used antibiotic for prophylaxis. The onset of naloxone effect may be delayed by 30 minutes or more. Nov 14, 2018 cefazolin for injection, usp is supplied in 10 or 20 grams pharmacy bulk packages. It works by stopping the growth of bacteria cefazolin is available under the following different brand names.
So each dose administered would be between 7503000mg, depending on the severity of the infection being treated. Common side effects of cefazolin and dextrose for injection include. Jul 17, 20 cefazolin is a prescription medication used to treat bacterial infections, including lung, skin, bone, joint, stomach, blood, heart valve, and urinary tract infections. First of all, drug provocation tests with this parenteral cephalosporin are. Rocephin is a white to yellowishorange crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. A broadspectrum cephalosporin antibiotic, c14h14n8o4s3, that is given intravenously in the form of its sodium salt. If contamination of drains or waterways occurs, advise. Ancef cefazolin is only available as an injectable, so it is usually only used in the hospital. Cefazolin for injection usp and dextrose injection usp fda. Section 2 solving dosage problems childrens wisconsin. Package insert cefazolinforinjectionusp anddextroseinjectionusp rxonly to reduce the development of drugresistant bacteria and maintain the effectiveness of cefazolin for injection usp and dextrose injection usp and other antibacterial drugs, cefazolin for injection usp and dextrose. Cefazolin definition of cefazolin by medical dictionary.