Antiinflammatory inhibition of the synthesis of prostaglandins. Take a small amount of the aspirin tablet and dissolve as much as you can in 3 drops of ethyl acetate. Aspirin acetylsalicylic acid is a painrelieving compound. The purpose of this lab is to synthesize and characterize high purity aspirin. Synopsis the objective of this experiment is to enable us to conduct the synthesis of aspirin, reinforce the skills of recrystallisation an. Synthesis of paracetamol morning paracetamol is made by reacting 4aminophenol with ethanoic anhydride more commonly called acetic anhydride. Aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as antiinflammatory medication. Ester synthesis lab student handout lab report components. When the reaction is complete the paracetamol is then isolated and purified. Experiment 11 synthesis and analysis of aspirin introduction aspirin is most widely sold overthecounter drug. The aspirin synthesized in this experiment will be crystallized from solution.
Synthesis of aspirin experiment chemistry libretexts. By calculating the theoretical yield based on the original amount of salicylic acid, one could determine the actual yield percentage of the reaction. This paper describes the first of our organic synthesis experiments, the synthesis, purification, and qualitative spectroscopic characterization of aspirin. Report data collected and subsequent calculations to all equipment should be returned to. Crystallization will be induced by scratching the glass beaker to create nuclei around which aspirin may crystallize. Synthesis of aspirin report data collected and subsequent calculations to all equipment should be returned to the correct location after use. Table 2 results parameter value calculations salicylic acid mol acetic anhydride mol theoretical yield of aspirin g weight of aspirin g. All minor components described in the how to write a strong lab report general guidelines note that the only chemical characterization test results you need report on are for the ferric chloride test.
Aspirin can be made by reacting salicylic acid with acetic acid in the presence of an acid catalyst. The synthesis of aspirin procedure steps 3 5 were repeated twice more for two more titrations. Preparation and standardization of hcl procedure part 4. The solid aspirin product will be separated from the reaction mixture by suction filtration and further purified by recrystallization. Determine the melting point of your aspirin sample your instructor will demonstrate how to use the melttemp apparatus.
Quantitative analysis of aspirin further analysis conclusion the overall objectives of. Give the balanced equation for the synthesis of aspirin, drawing the structures by hand. Synthesis and recrystallization of aspirin lab report uk essays. Experiment 22 synthesis of aspirin and oil of wintergreen. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. The calculated mass of acetic anhydride was calculated using its known density for a mass of 5. If you need guidance, follow the steps in the report sheets. Pdf preparing a pure aspirin acetylsalicylic acid researchgate. It is safe to discard of the filtrate down the sink with water. Synthesis and characterization of aspirin purpose the purpose of this lab was to synthesize aspirin and measure the synthesized aspirins purity. Synthesis of aspirin pre lab assignment study the sections related to stoichiometry and limiting reactant in your textbook. Wear safety glasses do experiment with your lab partner.
In the presence of moisture, aspirin may decompose hydrolysis into salicylic acid and acetic acid. The main procedures are preparation of aspirin, recrystallisation of aspirin and lastly determining the melting point of the aspirin. Aspirin is primarily used to treat pain as well as to avert cardiovascular disease. You will need to add up molar masses by counting the atoms shown in the structures. Do not lose this container or its contents, you will use them later. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group4. Pdf this aim of this experiment focuses on the synthesis of pure aspirin. The aspirin isolated in this step is the crude product. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. It has the ability to reduce fever an antipyretic, to reduce pain an analgesic, and to reduce swelling, soreness, and redness an antiinflammatory agent. You will be able to see how two very different organic compounds can be made from the same common starting material.
H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves. H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves heat the flask gently on the steam bath for at least 10 minutes. The use of aspirin had its origin in the 18 th century, when it was found that an. The methods used included recrystallization and scratching to produce a precipitate, which was then filtered to remove any excess moisture. For preparation of aspirin, acetic anhydride is added to the measured amount of salicylic acid. Aspirin is an effective analgesic pain reliever, antipyretic fever reducer and antiinflammatory agent and is one of the most widely used nonprescription drugs. The use of aspirin had its origin in the 18th century, when it was found that an extract from the.
Acetylsalicylic acid commonly known as aspirin is the most widely used drug in the world today. It is a mild analgesic, useful in the alleviation of bodily pains and aches, and it also possesses antiinflammatory properties useful in reducing fever. The purpose of this experiment was to make aspirin via esterification, and to determine the percent yield we as a lab group made. When salicylic acid reacts with acetic anhydride in the presence of an acid catalyst, acetylsalicylic acid, or aspirin, is produced according to the following equation. Generate an infrared spectrum of your aspirin sample your instructor will demonstrate how to use the ft. View notes aspirin synthesis lab report from chem 106 at case western reserve university. Synthesis of aspirin lab report free download as word doc. Transfer the salicylic acid into a second 125ml erlenmeyer flask not the one with the water in it, and record the mass of the salicylic acid on your report sheet. The synthesis and analysis of aspirin mariam elmagbri department of chemistry, american university, washington, d. The purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid aspirin, and to become familiar with the optimum conditions needed for successful yields. Chemistry 51 experiment 11 synthesis and analysis of aspirin.
The complete lab report must be typed this includes the calculations prepare a cover page. This reaction is the reverse of the synthesis reaction. Let this material sit at room temperature until the next lab period when you will determine your aspirin recovery. Preparation of aspirin experiment 5 lab report name first lastmcgill id number demonstrator section lab date complete table 2, showing all calculations. Based on the mass of salicylic acid 2 g determine the maximum yield of aspirin theoretical. Synthesis of aspirin lab report introduction the purpose of this experiment was to synthesize a small. Table 2 results parameter value calculations salicylic acid mol acetic anhydride mol theoretical yield. Terms in this set 57 synthesis of aspirinin the synthesis of aspirin, you will treat salicylic acid with acetic anhydridein order to proceed, the reaction requires an acid catalyst phosphoric acid. Since acetic acid is very soluble in water, it is easily separated from the aspirin product. Aspirin synthesis tap water was heated on a steam bath in a 250 ml beaker. After synthesis and analysis, it will be determined if the crude and recrystallized samples were composed solely of either salicylic acid, acetylsalicylic acid, or a combination of both 3. The purpose of this experiment is to synthesize the common pain killer aspirin via an esterification reaction between salicylic acid and acetic anhydride in the presence of concentrated sulfuric acid acting as a catalyst. Synthesis of aspirin lab report molar concentration. Synthesis of aspirin acetylsalicylic acid objectives aspirin, the wonder drug, is an important chemical worldwide.
Aspirin synthesis lab report by alissa lockwood on prezi. This bibliography was generated on cite this for me on monday, august 24, 2015. These are the sources and citations used to research synthesis of aspirin. Aspirin background also known as acetylsalicylic acid abbreviated asa, is a salicylate drug. This reaction forms an amide bond and ethanoic acid as a byproduct.
Aspirin acetylsalicylic acid is a painrelieving compound familiar to virtually all students. The purpose of this lab was to synthesize aspirin, determine the theoretical yield, compare the percent yield to the theoretical yield and test the purity of aspirin by adding iron iii. Jan 25, 2018 aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as antiinflammatory medication. Preparation, purification and analysis of aspirin acetylsalicylic acid. The main objective of the synthesis of aspirin lab was so produce aspirin acetylsalicylic acid through the reaction of salicylic acid and acetic anhydride. Synthesis of aspirin lab report and analysis odinity. In addition, it can prevent blood clotting, meaning in small amounts it can be helpful in preventing heart attacks or stroke. The aspirin product is not very soluble in water so the aspirin product will precipitate when water is added. Aspirin synthesis your team of scientists has been hired by the drug research division of santa monica pharmaceuticals, a new startup company formed by some smc alumni. This author provides an excellent student labreport format, explains how it adapts to different science disciplines, and suggests simple labs to familiarize students with it. Waste salicylic acid should be disposed of in the solid waste container. Two ester derivatives of this acid, synthesized as shown, are currently in common.
Synthesizing aspirin and oil of wintergreen purpose in this experiment, you will synthesize acetylsalicylic acid, commonly known as aspirin, and methyl salicylate, oil of wintergreen, from salicylic acid. This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. Experiment 8 synthesis of aspirin aspirin is an effective analgesic pain reliever, antipyretic fever reducer and antiinflammatory agent and is one of the most widely used nonprescription drugs. Synthesis and recrystallization of aspirin lab report. To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid 1 to form acetylsalicylic acid 2. Organic synthesis of aspirin chemistry formal lab essay sample. In this experiment, you will measure the melting point of your synthesized asa product, salicylic acid, a crushed aspirin tablet, and pure asa from a manufacturer. The following must be included in your lab book in order to receive full credit. The synthesis of paracetamol can be broken down into 3.
Compound molecular weight hazards density melting point salicylic acid 8. Based on the mass of salicylic acid 2 g determine the maximum yield of aspirin theoretical yield from this amount of starting material. It is the twostep synthesis of aspirin starting from oil of wintergreen. Synthesis of aspirin lab report essay example for free newyorkessays database with more than 65000 college essays for studying. Report the theoretical yield and the percent yield of the aspirin product. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap.
This aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while using concentrated sulfuric acid as a catalyst for the. Measure out 3 g of salicylic acid on an analytical balance, recording its mass to the nearest 0. Aspirins chemical name is acetylsalicylic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phosphoric acid as a catalyst. An ester is a compound that is formed when an acid reacts with an alcohol, oh group. Aspirin was first isolated by felix hoffmann, a chemist with the german company bayer in 1897. You have been asked to evaluate a simple organic synthesis for aspirin and to determine if the synthesis merits further funding by santa monica pharmaceuticals. Abstract aspirin, or acetylsalicylic acid, is a widely used drug. Synthesis of aspirin lab report 2989 words bartleby.
Aspirin is one of the milder and least expensive pain relievers available. Aspirin is an ester that has high molecular weight and it not soluble in water hence the solid can be separated by crystallization process. Though aspirin has numerous benefits, there are several adverse affects as well. Synthesis of aspirin prelab assignment study the sections related to stoichiometry and limiting reactant in your textbook. Synthesis of aspirin chemistry bibliographies cite. Synthesis of aspirin aspirin is the single most manufactured drug in the world. Aug 08, 2016 synthesis of aspirin lab report essay example for free newyorkessays database with more than 65000 college essays for studying. Organic synthesis of aspirin abstract the purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid aspirin, and to become familiar with the optimum conditions needed for successful yields. Aspirin is one the best known and most widely used medicines in modern society.